Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.43 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345066 | 0.92 | TDP1 (0.43) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3345108 | 0.90 | ALDH1A1 (0.43) | TSHRPLA2G2APKMKDM4EALDH1A1 | |
| SCHEMBL3345067 | 0.84 | PPARG (0.42) | TDP1TSHRPKMPPARGPPARD | |
| SCHEMBL3348857 | 0.83 | PLA2G10 (0.46) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3344022 | 0.82 | PLA2G1B (0.49) | PLA2G10PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL3346104 | 0.82 | PLA2G10 (0.41) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3346049 | 0.82 | PLA2G2A (0.41) | PLA2G10PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL3348093 | 0.81 | PLA2G2A (0.45) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3344376 | 0.81 | PLA2G2A (0.55) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3345075 | 0.80 | TDP1 (0.49) | TDP1TSHRPLA2G10PLA2G1BPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |