Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302932 | 0.82 | RAB9A (0.46) | ADORA2AADORA1KDM4EALDH1A1GAA | |
| SCHEMBL3302092 | 0.76 | TSHR (0.55) | ADORA2AADORA1KDM4EALDH1A1MEN1 | |
| SCHEMBL3302089 | 0.75 | CHRM4 (0.46) | ADORA2AADORA1GAAMEN1KMT2A | |
| SCHEMBL3348239 | 0.74 | ADORA2A (0.70) | HSP90AB1ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL3351882 | 0.72 | ADORA2A (0.59) | HSP90AB1ADORA2AADORA1 | |
| SCHEMBL3303592 | 0.68 | ADORA2A (0.66) | ADORA2AADORA1 | |
| SCHEMBL31044888 | 0.66 | KDM4E (0.33) | ADORA2AADORA1KDM4EALDH1A1GAA | |
| SCHEMBL3351568 | 0.66 | ADORA2A (0.75) | ADORA2AADORA1 | |
| SCHEMBL13780035 | 0.64 | KDM4E (0.51) | HSP90AB1KDM4EALDH1A1MEN1GLA | |
| SCHEMBL5456062 | 0.64 | HSP90AB1 (0.45) | HSP90AB1KDM4EALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045008-A1 | AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |