Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345838 | 0.90 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL3345297 | 0.88 | MAPT (0.54) | ALDH1A1SMN1; SMN2GAAKMT2AMAPT | |
| SCHEMBL311291 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL3345243 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2GAAKMT2AMAPT | |
| SCHEMBL22028444 | 0.82 | SIRT6 (0.61) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL22942270 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL311018 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL3346862 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HTTGAAKMT2A | |
| SCHEMBL15994800 | 0.80 | SIRT6 (0.69) | ALDH1A1HTTKMT2AMAPTKDM4E | |
| SCHEMBL31458455 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |