Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345168 | 0.90 | ALDH1A1 (0.49) | ALDH1A1GAACYP2D6L3MBTL1SIRT6 | |
| SCHEMBL3345297 | 0.90 | MAPT (0.54) | ALDH1A1GAACYP2D6SMN1; SMN2MAPT | |
| SCHEMBL15994800 | 0.81 | SIRT6 (0.69) | ALDH1A1L3MBTL1SIRT6HTTMAPT | |
| SCHEMBL20591963 | 0.81 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2HTTMAPT | |
| SCHEMBL12312120 | 0.81 | SIRT6 (0.64) | ALDH1A1GAACYP2D6SIRT6SMN1; SMN2 | |
| SCHEMBL3345216 | 0.79 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1HTTMAPTKDM4E | |
| SCHEMBL2205835 | 0.78 | TDP1 (0.49) | ALDH1A1GAACYP2D6L3MBTL1SIRT6 | |
| SCHEMBL12312118 | 0.78 | HTT (0.61) | ALDH1A1GAACYP2D6L3MBTL1SMN1; SMN2 | |
| SCHEMBL3346195 | 0.78 | MAPT (0.41) | ALDH1A1GAACYP2D6SIRT6SMN1; SMN2 | |
| SCHEMBL3320231 | 0.77 | ALDH1A1 (0.57) | ALDH1A1GAASIRT6SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |