Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345168 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2L3MBTL1GAAMAPT | |
| SCHEMBL3345950 | 0.78 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2L3MBTL1GAAMAPT | |
| SCHEMBL3314202 | 0.77 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2L3MBTL1HSP90AA1GAA | |
| SCHEMBL15994494 | 0.77 | MAPT (0.46) | ALDH1A1L3MBTL1MAPTLMNADRD2 | |
| SCHEMBL3345724 | 0.74 | MAPT (0.57) | ALDH1A1SMN1; SMN2GAAMAPTLMNA | |
| SCHEMBL3349756 | 0.73 | MAPT (0.56) | ALDH1A1SMN1; SMN2GAAMAPTLMNA | |
| SCHEMBL5074347 | 0.72 | HPGD (0.42) | ALDH1A1L3MBTL1GAAMAPTLMNA | |
| SCHEMBL3345838 | 0.72 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2L3MBTL1GAAMAPT | |
| SCHEMBL25301580 | 0.72 | MAPT (0.49) | ALDH1A1SMN1; SMN2GAAMAPTLMNA | |
| SCHEMBL16095184 | 0.72 | MAPT (0.52) | ALDH1A1SMN1; SMN2L3MBTL1HSP90AA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |