Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345903 | 0.83 | MAPT (0.43) | ALDH1A1LMNASMN1; SMN2MAPTDRD2 | |
| SCHEMBL2205562 | 0.78 | ALDH1A1 (0.47) | ALDH1A1POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3345243 | 0.78 | ALDH1A1 (0.40) | ALDH1A1POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL3346195 | 0.78 | MAPT (0.41) | ALDH1A1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL3318884 | 0.77 | ALDH1A1 (0.51) | ALDH1A1POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3346768 | 0.75 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTMAPK1KDM4E | |
| SCHEMBL16095184 | 0.74 | MAPT (0.52) | ALDH1A1POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL15994494 | 0.74 | MAPT (0.46) | ALDH1A1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL310051 | 0.72 | ALDH1A1 (0.52) | ALDH1A1POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3346986 | 0.72 | GAA (0.39) | ALDH1A1POLBMAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |