Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | ABL2 | P42684 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3352394 | 1.00 | KCNH2 (0.41) | KCNH2XDHSSTR4ABL1SRC | |
| SCHEMBL3345358 | 0.87 | LRRK2 (0.41) | KCNH2SSTR4RORCLRRK2 | |
| SCHEMBL3347090 | 0.87 | RORC (0.40) | KCNH2PDE4DRORC | |
| SCHEMBL3345353 | 0.87 | LRRK2 (0.41) | KCNH2SSTR4RORCLRRK2 | |
| SCHEMBL3347085 | 0.87 | RORC (0.40) | KCNH2PDE4DRORC | |
| SCHEMBL3378590 | 0.84 | CHEK1 (0.39) | KCNH2XDHABL1SRCABL2 | |
| SCHEMBL3378593 | 0.84 | CHEK1 (0.39) | KCNH2XDHABL1SRCABL2 | |
| SCHEMBL3345752 | 0.83 | LRRK2 (0.39) | RORCLRRK2 | |
| SCHEMBL3345749 | 0.83 | LRRK2 (0.39) | RORCLRRK2 | |
| SCHEMBL3345692 | 0.82 | LRRK2 (0.37) | KCNH2SSTR4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |