Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.35 |
| ▸ | TUBB | P07437 | 3/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345793 | 0.91 | GAK (0.38) | ALDH1A1HTTGAACYP3A4SMN1; SMN2 | |
| SCHEMBL3352155 | 0.82 | ALDH1A1 (0.43) | ALDH1A1LMNAHTTTUBB4ATUBB | |
| SCHEMBL3314122 | 0.79 | L3MBTL1 (0.40) | ALDH1A1LMNAHTTL3MBTL1TUBB4A | |
| SCHEMBL15651237 | 0.78 | IGF1R (0.41) | ALDH1A1LMNAHTTL3MBTL1TUBB4A | |
| SCHEMBL13362043 | 0.74 | ALK (0.38) | ALDH1A1CYP3A4DPP4IGF1RKCNH2 | |
| SCHEMBL3313268 | 0.73 | IGF1R (0.47) | ALDH1A1GAACYP3A4DPP4IGF1R | |
| SCHEMBL13362091 | 0.72 | KCNH2 (0.39) | L3MBTL1CYP3A4MEN1KMT2AIGF1R | |
| SCHEMBL13362030 | 0.71 | IGF1R (0.42) | ALDH1A1GAACYP3A4DPP4IGF1R | |
| SCHEMBL13362108 | 0.71 | GAK (0.42) | ALDH1A1HTTGAACYP3A4DPP4 | |
| SCHEMBL30900296 | 0.71 | ALDH1A1 (0.41) | ALDH1A1LMNAHTTL3MBTL1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |