Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
| ▸ | TUBB | P07437 | 2/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345809 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL3315577 | 0.81 | ALDH1A1 (0.51) | ALDH1A1LMNASIRT6KMT2AMEN1 | |
| SCHEMBL3345793 | 0.80 | GAK (0.38) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3314034 | 0.77 | SIRT6 (0.55) | ALDH1A1LMNASIRT6MAPK1MAPT | |
| SCHEMBL30900295 | 0.76 | SIRT6 (0.55) | ALDH1A1LMNASIRT6KMT2AMEN1 | |
| SCHEMBL3315135 | 0.75 | ALDH1A1 (0.52) | ALDH1A1LMNASIRT6KMT2AMAPK1 | |
| SCHEMBL4802163 | 0.73 | GHSR (0.52) | ALDH1A1LMNASIRT6KMT2AMAPT | |
| SCHEMBL4802144 | 0.73 | GHSR (0.52) | ALDH1A1LMNASIRT6KMT2AMAPT | |
| SCHEMBL15994800 | 0.73 | SIRT6 (0.69) | ALDH1A1LMNASIRT6KMT2AMAPK1 | |
| SCHEMBL30900362 | 0.71 | SIRT6 (0.49) | ALDH1A1LMNASIRT6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |