Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348194 | 0.87 | KCNH2 (0.63) | KCNH2HDAC4MC4R | |
| SCHEMBL3415193 | 0.84 | KCNH2 (0.65) | KCNH2MC4R | |
| SCHEMBL3346412 | 0.81 | CNR1 (0.53) | KCNH2KDM4EHSD17B10MC4R | |
| SCHEMBL3350871 | 0.80 | KCNH2 (0.57) | KCNH2HIF1AKDM4EMC4RLMNA | |
| SCHEMBL22179085 | 0.79 | MC4R (0.58) | HIF1AKDM4EHSD17B10MC4RLMNA | |
| SCHEMBL3346268 | 0.78 | KCNH2 (0.55) | KCNH2HDAC4MC4R | |
| SCHEMBL3345898 | 0.78 | KCNH2 (0.54) | KCNH2HDAC4TRPV1 | |
| Hydrochloric Acid SCHEMBL22160560 | 0.77 | MC4R (0.57) | HIF1AKDM4EHSD17B10MC4RLMNA | |
| SCHEMBL3346435 | 0.75 | KCNH2 (0.58) | KCNH2MC4R | |
| SCHEMBL3348192 | 0.74 | KCNH2 (0.57) | KCNH2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |