Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347208 | 0.82 | DYRK1A (0.36) | GRM5DYRK1AOGASCN5ATGFBR1 | |
| SCHEMBL3346192 | 0.82 | GRM5 (0.47) | GRM5DYRK1AOGASCN5AKIT | |
| SCHEMBL3345917 | 0.82 | GRM5 (0.44) | GRM5DYRK1AOGASCN5ATGFBR1 | |
| SCHEMBL3346819 | 0.79 | SCN5A (0.39) | GRM5DYRK1AOGASCN5APTGDR2 | |
| SCHEMBL3347519 | 0.78 | GRM4 (0.46) | GRM5DYRK1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3351686 | 0.78 | GRM5 (0.49) | GRM5KCNH2DYRK1AOGASCN5A | |
| SCHEMBL3348828 | 0.77 | TGFBR1 (0.39) | GRM5DYRK1AOGASCN5ATGFBR1 | |
| SCHEMBL3347027 | 0.77 | GRM5 (0.50) | GRM5KCNH2DYRK1ATGFBR1CYP1A2 | |
| SCHEMBL3347011 | 0.77 | DYRK1A (0.41) | GRM5KCNH2DYRK1ASCN5ATGFBR1 | |
| SCHEMBL3351121 | 0.76 | GRM5 (0.34) | GRM5DYRK1AKCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |