Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345917 | 0.82 | GRM5 (0.44) | DYRK1AOGASCN5AGRM5TGFBR1 | |
| SCHEMBL3346192 | 0.82 | GRM5 (0.47) | DYRK1AOGASCN5AGRM5TGFBR1 | |
| SCHEMBL3346833 | 0.82 | GRM5 (0.50) | DYRK1AOGASCN5AGRM5TGFBR1 | |
| SCHEMBL2177472 | 0.81 | DYRK1A (0.44) | DYRK1AOGASCN5ACDK2TGFBR1 | |
| SCHEMBL3346819 | 0.79 | SCN5A (0.39) | DYRK1AOGASCN5AGRM5TGFBR1 | |
| SCHEMBL3347519 | 0.78 | GRM4 (0.46) | DYRK1AGRM5KDM4E | |
| SCHEMBL3348828 | 0.77 | TGFBR1 (0.39) | DYRK1AOGASCN5AGRM5TGFBR1 | |
| SCHEMBL3347261 | 0.77 | GRM5 (0.47) | GRM5 | |
| SCHEMBL3347027 | 0.77 | GRM5 (0.50) | DYRK1AGRM5TGFBR1 | |
| SCHEMBL3347789 | 0.74 | GRM5 (0.49) | DYRK1AOGASCN5AGRM5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |