Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348887 | 0.88 | GRM5 (0.38) | GRM5SLC6A2DYRK1AADORA2BCA12 | |
| SCHEMBL3346845 | 0.85 | DYRK1A (0.40) | DYRK1ARAB9A | |
| SCHEMBL3346390 | 0.84 | DYRK1A (0.36) | GRM5DYRK1ANPC1HPGDTSHR | |
| SCHEMBL3346361 | 0.82 | GRM5 (0.41) | GRM5ADORA2BCA12CA1CA2 | |
| SCHEMBL3346741 | 0.80 | ADORA2B (0.42) | GRM5SLC6A2DYRK1AADORA2BCHRM2 | |
| SCHEMBL3347295 | 0.79 | GRM5 (0.48) | GRM5SLC6A2DYRK1ACA12CA1 | |
| SCHEMBL3348360 | 0.78 | GRM5 (0.44) | GRM5MEN1NPC1ALDH1A1TSHR | |
| SCHEMBL3348379 | 0.76 | CYP11B1 (0.38) | DYRK1AMEN1NPC1ALDH1A1TSHR | |
| SCHEMBL3346526 | 0.73 | GRM5 (0.37) | GRM5DYRK1ACHRM2CHRM1 | |
| SCHEMBL3346840 | 0.73 | GRM5 (0.36) | GRM5DYRK1AADORA2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |