Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CBLB | Q13191 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346995 | 0.83 | GRM5 (0.56) | GRM5MEN1TSHRKMT2AKDR | |
| SCHEMBL3347015 | 0.80 | MEN1 (0.50) | GRM5MEN1TSHRKMT2ACBLB | |
| SCHEMBL3346207 | 0.78 | GRM5 (0.36) | GRM5MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL3346845 | 0.78 | DYRK1A (0.40) | RAB9A | |
| SCHEMBL3346361 | 0.77 | GRM5 (0.41) | GRM5 | |
| SCHEMBL3346390 | 0.77 | DYRK1A (0.36) | GRM5TSHRKDM4ERAB9ANPC1 | |
| SCHEMBL3346840 | 0.71 | GRM5 (0.36) | GRM5SMN1; SMN2 | |
| SCHEMBL3348249 | 0.69 | KDR (0.64) | GRM5KDRPDGFRBKDM4ESMN1; SMN2 | |
| SCHEMBL3346526 | 0.69 | GRM5 (0.37) | GRM5 | |
| SCHEMBL21715154 | 0.68 | GRM5 (0.58) | GRM5MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |