Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 9/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348895 | 0.86 | CHRM2 (0.40) | CHRM2CHRM1GRM5CHRNB2CHRNA4 | |
| SCHEMBL3347005 | 0.86 | ALOX5 (0.40) | ADORA2BGRM5CHRNB2CHRNA4DYRK1A | |
| SCHEMBL3347130 | 0.85 | CA12 (0.38) | CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3344268 | 0.83 | ADORA2B (0.40) | ADORA2BCHRM2CHRM1GRM5CHRNB2 | |
| SCHEMBL3346158 | 0.81 | CYP2A6 (0.44) | GRM5CHRNB2CHRNA4MELK | |
| SCHEMBL3346207 | 0.80 | GRM5 (0.36) | ADORA2BCHRM2CHRM1GRM5DYRK1A | |
| SCHEMBL3345871 | 0.79 | CHRM2 (0.35) | CHRM2CHRM1GRM5CHRNB2CHRNA4 | |
| SCHEMBL3346523 | 0.78 | CYP2A6 (0.35) | CHRM2CHRM1GRM5DYRK1ASCN5A | |
| SCHEMBL3348887 | 0.78 | GRM5 (0.38) | ADORA2BCHRM2CHRM1GRM5DYRK1A | |
| SCHEMBL3347295 | 0.76 | GRM5 (0.48) | GRM5DYRK1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |