Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346471 | 0.87 | GAA (0.51) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL4210140 | 0.83 | GAA (0.71) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL3020727 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL3499191 | 0.80 | MAPT (0.62) | SMN1; SMN2GAAALDH1A1CYP2C19CHRM1 | |
| SCHEMBL12987073 | 0.80 | — | — | |
| SCHEMBL8259432 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2NPC1GAAALDH1A1CHRM1 | |
| SCHEMBL11578382 | 0.79 | GAA (0.56) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL20827152 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL5454532 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL5676009 | 0.77 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053732-A1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |