Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347810 | 0.87 | — | — | |
| SCHEMBL3345946 | 0.85 | GRM5 (0.39) | GRM5CYP1A2CYP2D6PDE10A | |
| SCHEMBL3347648 | 0.83 | GRM5 (0.33) | GRM5PDE10A | |
| SCHEMBL3346746 | 0.83 | KCNN1 (0.38) | GRM5PDE10A | |
| SCHEMBL3345891 | 0.83 | — | — | |
| SCHEMBL3347071 | 0.83 | CYP2A6 (0.32) | PDE10A | |
| SCHEMBL3346499 | 0.82 | CDK2 (0.35) | PDE10A | |
| SCHEMBL3351751 | 0.82 | CDK2 (0.38) | GRM5PDE10A | |
| SCHEMBL3351298 | 0.82 | GRM5 (0.33) | GRM5 | |
| SCHEMBL3346921 | 0.81 | KCNN3 (0.37) | GRM5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |