Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN1 | Q92952 | 1/20 | 0.38 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346499 | 0.87 | CDK2 (0.35) | KCNN1KCNN2KCNN3CDK5CDK2 | |
| SCHEMBL3347071 | 0.85 | CYP2A6 (0.32) | KCNN1KCNN2KCNN3CDK5CDK2 | |
| SCHEMBL3347648 | 0.84 | GRM5 (0.33) | KCNN1KCNN2KCNN3GRM5CDK2 | |
| SCHEMBL3351751 | 0.84 | CDK2 (0.38) | KCNN1KCNN2KCNN3GRM5CDK5 | |
| SCHEMBL3351298 | 0.84 | GRM5 (0.33) | GRM5 | |
| SCHEMBL3348362 | 0.83 | CDK2 (0.39) | GRM5CDK2CCNE1 | |
| SCHEMBL3345946 | 0.83 | GRM5 (0.39) | KCNN3GRM5CDK2KDM4EALDH1A1 | |
| SCHEMBL3346921 | 0.83 | KCNN3 (0.37) | KCNN3GRM5CDK2CCNE1CCNT1 | |
| SCHEMBL3346510 | 0.83 | GRM5 (0.37) | GRM5PDE10A | |
| SCHEMBL3347209 | 0.83 | KCNN3 (0.36) | KCNN1KCNN2KCNN3GRM5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |