Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CDK7 | P50613 | 3/20 | 0.38 |
| ▸ | CCNH | P51946 | 3/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.38 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347564 | 0.89 | GRM5 (0.33) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3347209 | 0.89 | KCNN3 (0.36) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3346499 | 0.87 | CDK2 (0.35) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3347648 | 0.84 | GRM5 (0.33) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3346746 | 0.84 | KCNN1 (0.38) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3345946 | 0.83 | GRM5 (0.39) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3346921 | 0.83 | KCNN3 (0.37) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3347071 | 0.83 | CYP2A6 (0.32) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL3346510 | 0.82 | GRM5 (0.37) | PDE10AGRM5 | |
| SCHEMBL3348362 | 0.82 | CDK2 (0.39) | CDK2CCNE1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |