Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347267 | 0.74 | TGFBR1 (0.45) | PIM1MAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL15286421 | 0.71 | CAMKK1 (0.56) | PIM1MAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL3346996 | 0.69 | MEN1 (0.41) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL465339 | 0.69 | — | — | |
| Benzene SCHEMBL28686547 | 0.69 | ALDH1A1 (0.45) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL29730399 | 0.67 | ALDH1A1 (0.43) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL27780348 | 0.67 | ALDH1A1 (0.43) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL27820487 | 0.67 | ALDH1A1 (0.43) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL1358827 | 0.63 | ALDH1A1 (0.39) | MEN1KMT2ALMNA | |
| SCHEMBL28126651 | 0.63 | TSHR (0.42) | MAPTSMN1; SMN2MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |