Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581826 | 0.83 | CYP11B2 (0.44) | CYP11B2MAPTBACE1CTSDBACE2 | |
| SCHEMBL3351358 | 0.82 | CYP11B2 (0.40) | CYP11B2CYP11B1MAPTGRM5CSNK1A1 | |
| SCHEMBL3348429 | 0.82 | GRM5 (0.44) | GRM5 | |
| SCHEMBL28884696 | 0.78 | GRM5 (0.40) | GRM5 | |
| SCHEMBL29934042 | 0.78 | GRM5 (0.40) | GRM5 | |
| SCHEMBL3348980 | 0.77 | GRM5 (0.56) | CYP11B2CYP11B1GRM5 | |
| SCHEMBL22531723 | 0.70 | GRM5 (0.38) | GRM5 | |
| SCHEMBL12938274 | 0.69 | GRM5 (0.39) | CHRNB2GRM5 | |
| SCHEMBL29889779 | 0.69 | CYP2A6 (0.55) | CYP11B2CYP11B1MAPT | |
| SCHEMBL15730135 | 0.69 | CYP11B2 (0.48) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |