Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346852 | 0.82 | CYP11B2 (0.47) | GRM5 | |
| SCHEMBL3348352 | 0.81 | ALOX5AP (0.41) | GRM5ALOX5APFEN1LOXL2BTK | |
| SCHEMBL3347498 | 0.77 | GRM5 (0.41) | GRM5ABL1CHEK1LOXL2 | |
| SCHEMBL28884696 | 0.76 | GRM5 (0.40) | GRM5 | |
| SCHEMBL29934042 | 0.76 | GRM5 (0.40) | GRM5 | |
| SCHEMBL3348980 | 0.75 | GRM5 (0.56) | GRM5 | |
| SCHEMBL30108242 | 0.73 | CYP2A6 (0.50) | ABL1ALOX5APFEN1PDE10ABTK | |
| SCHEMBL29501236 | 0.70 | BTK (0.50) | ALOX5APFEN1LOXL2PDE10ABTK | |
| SCHEMBL17165362 | 0.70 | PTGS2 (0.38) | — | |
| SCHEMBL26426502 | 0.70 | GRM5 (0.52) | GRM5BTKCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |