Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576748 | 0.85 | SIGMAR1 (0.44) | CA2CA12CA1CA9CHKA | |
| SCHEMBL23123827 | 0.85 | CA2 (0.39) | CA2CA12CA1CA9CHKA | |
| Hydrochloric Acid SCHEMBL17560465 | 0.84 | SIGMAR1 (0.43) | CA2CA12CA1CA9CHKA | |
| Hydrochloric Acid SCHEMBL29267259 | 0.84 | CA2 (0.38) | CA2CA12CA1CA9CHKA | |
| SCHEMBL3347181 | 0.82 | HRH3 (0.40) | CHRNB2CHRNA3CHRNA4HRH3CHRNB4 | |
| SCHEMBL9760358 | 0.82 | HRH3 (0.43) | CHRNB2CHRNA3CHRNA4HRH3CHRNB4 | |
| SCHEMBL8521197 | 0.82 | SIGMAR1 (0.41) | CA2CA12CA1CA9CHKA | |
| SCHEMBL3345211 | 0.81 | HRH3 (0.46) | HRH3 | |
| SCHEMBL5958440 | 0.81 | CA2 (0.42) | CA2CA12CA1CA9CHKA | |
| SCHEMBL391242 | 0.81 | MEN1 (0.40) | CA2CA12CA1CA9CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | claimed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| EP-0620814-A1 | NOVEL PIPRAZINE CARBOXAMIDES | Pharmacia & Upjohn Aktiebolag (SE) | 1994-10-26 | — | — | EP | disclosed |
| WO-1994003436-A1 | NOVEL PIPRAZINE CARBOXAMIDES | KABI PHARMACIA AB (SE) | 1994-02-17 | — | — | WO | disclosed |