Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760358 | 0.96 | HRH3 (0.43) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3345211 | 0.94 | HRH3 (0.46) | HRH3 | |
| SCHEMBL3315257 | 0.84 | HRH3 (0.35) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18389972 | 0.84 | HTR1A (0.53) | HRH3HTR1A | |
| SCHEMBL3317327 | 0.82 | HRH3 (0.38) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3347099 | 0.82 | CA2 (0.39) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18389978 | 0.81 | HRH3 (0.50) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18705034 | 0.80 | HRH3 (0.36) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9760411 | 0.79 | HRH3 (0.44) | HRH3 | |
| SCHEMBL26725202 | 0.78 | HRH3 (0.46) | HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | claimed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |