Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13036727 | 0.91 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL940 | 0.90 | GP6 (0.56) | GP6AGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL13755335 | 0.89 | AGTR1 (0.58) | GP6AGTR1AGTR2ABCC4ABCB11 | |
| SCHEMBL3347424 | 0.89 | GP6 (0.53) | GP6AGTR1AGTR2ABCC4ABCB11 | |
| Losartan SCHEMBL60 | 0.89 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL6092394 | 0.89 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL29383742 | 0.89 | AGTR1 (0.67) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL7420948 | 0.88 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL1628706 | 0.88 | AGTR1 (0.60) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL17031402 | 0.88 | GP6 (0.51) | GP6AGTR1AGTR2ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144810-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2010-06-10 | — | — | US | claimed |
| WO-2010065432-A1 | NITROOXY DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-06-10 | — | — | WO | claimed |
| US-8293777-B2 | Angiotensin II receptor antagonists | MERCK SHARP & DOHME, CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-7858651-B2 | Imidazole-5-carboxylic acid derivatives, the preparation method therefor and the uses thereof | SHANGHAI ALLIST PHARMACEUTICAL, INC. (CN) | 2010-12-28 | — | — | US | disclosed |
| US-20100144810-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2010-06-10 | — | — | US | disclosed |
| US-20090036505-A1 | Imidazole-5-Carboxylic Acid Derivatives, The Preparation Method Therefor and The Uses Thereof | SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD (CN) | 2009-02-05 | — | — | US | disclosed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036505-A1 | Imidazole-5-Carboxylic Acid Derivatives, The Preparation Method Therefor and The Uses Thereof | AGTR2, AGTR1, REN | GP6 2440/4885AGTR1 2/4885AGTR2 1/4885 |
| US-20100144810-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | AGTR1, AGTR2, REN | GP6 1538/4885AGTR1 1/4885AGTR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.