Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351706 | 0.88 | KDM4E (0.34) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346926 | 0.86 | GRM5 (0.38) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3345928 | 0.83 | GRM5 (0.36) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346239 | 0.81 | GRM5 (0.39) | GRM5PDE10A | |
| SCHEMBL3345594 | 0.81 | GRM5 (0.40) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3347055 | 0.80 | GRM5 (0.51) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346856 | 0.79 | GRM5 (0.52) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3345574 | 0.79 | GRM5 (0.34) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3347641 | 0.78 | GRM5 (0.38) | GRM5KDM4EALDH1A1MAPK1HTT | |
| SCHEMBL3346938 | 0.78 | GRM5 (0.43) | GRM5KDM4EALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |