Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345928 | 0.89 | GRM5 (0.36) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3346940 | 0.89 | GRM5 (0.42) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3345594 | 0.89 | GRM5 (0.40) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3346840 | 0.85 | GRM5 (0.36) | GRM5HTTFFAR1SMN1; SMN2ADORA2B | |
| SCHEMBL3347306 | 0.84 | CHRNB2 (0.44) | GRM5 | |
| SCHEMBL3346856 | 0.82 | GRM5 (0.52) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3347664 | 0.81 | GRM5 (0.37) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3351706 | 0.80 | KDM4E (0.34) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3346938 | 0.79 | GRM5 (0.43) | GRM5ALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL3347055 | 0.78 | GRM5 (0.51) | GRM5ALDH1A1HTTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |