SCHEMBL3347915

SCHEMBL3347915

Fc1cc(F)cc(Nc2nc(Cl)nc3c2ncn3CC(F)F)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.70
CTSS P25774 2/20 0.70
CTSC P53634 2/20 0.70
CTSZ Q9UBR2 2/20 0.70
KLK4 Q9Y5K2 2/20 0.70
NPC1 O15118 1/20 0.70
ELANE P08246 1/20 0.70
CMA1 P23946 1/20 0.70
CASP1 P29466 1/20 0.70
RAB9A P51151 1/20 0.70
CTSV O60911 1/20 0.53
CTSB P07858 1/20 0.53
CTSH P09668 1/20 0.53
CTSK P43235 1/20 0.53
CASP4 P49662 1/20 0.53
MMP14 P50281 1/20 0.53
BACE1 P56817 1/20 0.53
ADAM17 P78536 1/20 0.53
P2RY1 P47900 2/20 0.45
YTHDC1 Q96MU7 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3346407 0.82 CTSL (1.00) CTSLCTSSCTSCCTSZKLK4
SCHEMBL3348188 0.76 P2RX7 (0.48) CTSLCTSSCTSCCTSZKLK4
SCHEMBL5840317 0.75 CDK1 (0.68) CTSLCTSSCTSCCTSZKLK4
SCHEMBL5840144 0.74 CDK1 (0.65) CTSLCTSSCTSCCTSZKLK4
SCHEMBL183059 0.73 CDK2 (0.54) NPC1P2RY1YTHDC1CCNA2CDK2
SCHEMBL7207999 0.72 CDK1 (0.54) CTSLCTSSCTSCCTSZKLK4
SCHEMBL183315 0.68 SRC (0.61) NPC1YTHDC1CCNA2CDK2CCNA1
SCHEMBL3379300 0.68 YTHDC1 (0.60) NPC1YTHDC1CCNA2CDK2CCNA1
SCHEMBL7536448 0.68 YTHDC1 (0.74) YTHDC1CCNA2CDK2HDAC1HDAC2
SCHEMBL244036 0.68 SRC (0.55) CTSLCTSSCTSCCTSZKLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed