Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443247 | 0.87 | ALDH1A1 (0.55) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL3348041 | 0.79 | POLB (0.63) | MAPTSMN1; SMN2HTTALDH1A1POLB | |
| SCHEMBL31666079 | 0.76 | ALDH1A1 (0.48) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL26098464 | 0.76 | ALDH1A1 (0.48) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL14480641 | 0.76 | LMNA (0.56) | MAPTSMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL31666080 | 0.75 | TDP1 (0.56) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL26100476 | 0.75 | TDP1 (0.56) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL31666083 | 0.74 | ALDH1A1 (0.56) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL26098455 | 0.74 | ALDH1A1 (0.56) | MAPTSMN1; SMN2HTTKMT2ANPC1 | |
| SCHEMBL12301081 | 0.74 | KMT2A (0.70) | MAPTSMN1; SMN2HTTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010060532-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |