Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | QDPR | P09417 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345349 | 0.82 | QDPR (0.45) | PDE4BQDPRHTR4ALDH1A1 | |
| SCHEMBL28096990 | 0.78 | QDPR (0.43) | PDE4BSLC6A4QDPRHTR4ALDH1A1 | |
| SCHEMBL3345688 | 0.77 | CFB (0.41) | PDE4B | |
| SCHEMBL3345716 | 0.77 | PDE4B (0.45) | PDE4B | |
| SCHEMBL3313062 | 0.77 | QDPR (0.50) | PDE4BQDPRNR3C1PDE4APDE4C | |
| SCHEMBL3349380 | 0.74 | ALDH1A1 (0.40) | HTR4ALDH1A1 | |
| SCHEMBL14648374 | 0.72 | QDPR (0.45) | PDE4BQDPRALDH1A1PDE4APDE4C | |
| SCHEMBL29517150 | 0.72 | QDPR (0.68) | PDE4BHTR1AQDPRALDH1A1PDE4A | |
| SCHEMBL520554 | 0.72 | QDPR (0.68) | PDE4BHTR1AQDPRALDH1A1PDE4A | |
| SCHEMBL20725583 | 0.71 | QDPR (0.49) | SLC6A4QDPRHTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |