SCHEMBL3349055

SCHEMBL3349055

CCC(c1ccccn1)c1cc(C#N)c(N)s1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 7/20 0.40
SLC6A2 P23975 5/20 0.40
SLC6A4 P31645 5/20 0.40
SCN1A P35498 3/20 0.40
SCN2A Q99250 3/20 0.40
SCN3A Q9NY46 3/20 0.40
TSHR P16473 3/20 0.38
MEN1 O00255 2/20 0.37
GAA P10253 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CHRM1 P11229 6/20 0.36
KCNH2 Q12809 5/20 0.36
HRH1 P35367 4/20 0.36
SLC6A3 Q01959 4/20 0.36
HRH3 Q9Y5N1 4/20 0.36
CHRM5 P08912 4/20 0.36
ADRA2B P18089 3/20 0.36
HTR2A P28223 3/20 0.36
CHRM4 P08173 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3344813 0.75 GRIN2D (0.38) TSHRMEN1GAAKMT2ASMN1; SMN2
SCHEMBL3344814 0.75 MEN1 (0.34) TSHRMEN1GAAKMT2ASMN1; SMN2
SCHEMBL3910230 0.71 TSHR (0.62) CHRM2SLC6A2SLC6A4SCN1ASCN2A
SCHEMBL3300882 0.70 ADORA2A (0.66)
SCHEMBL3304121 0.70 ADORA2A (0.46) MEN1GAAKMT2ASMN1; SMN2LMNA
SCHEMBL13391754 0.68 ADORA2A (0.52)
Hydrochloric Acid SCHEMBL3300899 0.68 ADORA2A (0.51)
SCHEMBL13182065 0.68 IMPDH2 (0.48) CHRM2SLC6A2SLC6A4SCN1ASCN2A
SCHEMBL3299360 0.67 L3MBTL1 (0.42) TSHRMEN1GAAKMT2ASMN1; SMN2
SCHEMBL290075 0.66 SLC6A2 (0.67) CHRM2SLC6A2SLC6A4SCN1ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010045012-A1 HETEROARYL AND PHENYL SUBSTITUTED THIENO [2,3-D] PYRIMIDINES AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2010-04-22 WO disclosed