Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555690 | 1.00 | AKR1C3 (0.36) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL10580121 | 0.73 | LMNA (0.41) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL1667466 | 0.69 | AKR1C3 (0.36) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL2071309 | 0.68 | CYP2C19 (0.46) | ALDH1A1L3MBTL1POLBCYP2C19LMNA | |
| SCHEMBL7650701 | 0.68 | CYP2C19 (0.41) | POLBFFAR2CYP2C19 | |
| SCHEMBL4479342 | 0.67 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL6179952 | 0.67 | ALDH1A1 (0.44) | ALDH1A1FFAR2CYP2C19LMNA | |
| SCHEMBL5696122 | 0.67 | LMNA (0.39) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL24743434 | 0.66 | — | — | |
| SCHEMBL1574429 | 0.66 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010061398-A1 | PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-06-03 | — | — | WO | claimed |
| WO-2010061398-A1 | PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-06-03 | — | — | WO | disclosed |
| EP-1918293-A1 | Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid | Sandoz AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| EP-0296879-B1 | SUBSTITUTED AROMATIC SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4863922-A | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0296879-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-28 | — | — | EP | disclosed |