Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 4/20 | 0.50 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911431 | 1.00 | GABRR1 (0.50) | GABRR1GABRR2ALOX5HTTALDH1A1 | |
| SCHEMBL3493155 | 0.94 | ALOX5 (0.56) | GABRR1GABRR2ALOX5HTTALDH1A1 | |
| SCHEMBL3493080 | 0.94 | ALOX5 (0.56) | GABRR1GABRR2ALOX5HTTALDH1A1 | |
| SCHEMBL2411087 | 0.94 | ALOX5 (0.56) | GABRR1GABRR2ALOX5HTTALDH1A1 | |
| SCHEMBL24354392 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB | |
| SCHEMBL3491458 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB | |
| SCHEMBL17779527 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB | |
| SCHEMBL21972780 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB | |
| SCHEMBL11414522 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB | |
| SCHEMBL301664 | 0.92 | ALOX5 (0.59) | GABRR1GABRR2ALOX5ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-7727997-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7498436-B2 | Substituted hydroxyethylamines | PHARMACIA & UPJOHN COMPANY LLC (US) | 2009-03-03 | — | — | US | disclosed |
| CN-100366605-C | Compounds to treat alzheimer's disease | ELAN PHARM INC (US) | 2008-02-06 | — | — | CN | disclosed |
| CN-101090883-A | Substituted hydroxyethylamines | ELAN PHARM INC (US) | 2007-12-19 | — | — | CN | disclosed |
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. | 2007-09-13 | — | — | US | disclosed |
| US-20070213407-A1 | Compounds to treat Alzheimer's disease | ELAN PHARMACEUTICALS AND PHARMACIA & UPJOHN COMPANY LLC | 2007-09-13 | — | — | US | disclosed |
| US-7214715-B2 | Compounds to treat Alzheimer's disease | PHARMACIA & UPJOHN (US) | 2007-05-08 | — | — | US | disclosed |
| US-7176242-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-20060106256-A1 | Substituted hydroxyethylamines | PHARMACIA & UPJOHN COMPANY | 2006-05-18 | — | — | US | disclosed |
| EP-0205403-B1 | PROCESS FOR THE MANUFACTURE OF CYCLOPROPYLAMINE | CIBA-GEIGY AG (CH) | 1989-08-30 | — | — | EP | disclosed |
| EP-0205403-A1 | Process for the manufacture of cyclopropylamine | CIBA-GEIGY AG (CH) | 1986-12-17 | — | — | EP | disclosed |
| US-4590292-A | FROM GAMMA-BUTYROLACTONE | CIBA-GEIGY CORPORATION (US) | 1986-05-20 | — | — | US | disclosed |
| US-4570008-A | ORGANOLEPTICS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1986-02-11 | — | — | US | disclosed |
| US-4554095-A | PERFUMES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-11-19 | — | — | US | disclosed |
| US-4536330-A | ORGANOLEPTICS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4528142-A | 1-Hydroxymethyl-2-acyl cyclopropane derivatives and esters thereof | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4500448-A | PERFUMES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-02-19 | — | — | US | disclosed |
| US-4481225-A | ACETATE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-11-06 | — | — | US | disclosed |
| US-4435428-A | Use in augmenting or enhancing the aroma or taste of foodstuff or chewing gum with the methyl carbonate of 1-hydroxymethyl-2-heptanoyl cyclopropane | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213407-A1 | Compounds to treat Alzheimer's disease | PSEN2, PSEN1, CHAT | GABRR1 753/4885GABRR2 724/4885ALOX5 1122/4885 |
| US-20060106256-A1 | Substituted hydroxyethylamines | HNMT, PNMT, BCHE | GABRR1 2987/4885GABRR2 2853/4885ALOX5 2257/4885 |
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | BACE1, BACE2, APP | GABRR1 732/4885GABRR2 899/4885ALOX5 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.