SCHEMBL3350857

SCHEMBL3350857

CO[Si](OC)(OC)c1ccc(C=Cc2ccc([Si](OC)(OC)OC)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CYP3A4 P08684 2/20 0.43
NPC1 O15118 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RAB9A P51151 1/20 0.43
TRPA1 O75762 1/20 0.41
RELA Q04206 1/20 0.41
MAPT P10636 2/20 0.41
TUBB4A P04350 4/20 0.40
TUBB P07437 4/20 0.40
TUBA3C P0DPH7 4/20 0.40
TUBA1B P68363 4/20 0.40
TUBA4A P68366 4/20 0.40
TUBB4B P68371 4/20 0.40
TUBB3 Q13509 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3350851 1.00 CYP1A2 (0.43) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4
SCHEMBL13429716 0.89 TUBB1 (0.53) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4
SCHEMBL5879114 0.89 CYP3A4 (0.54) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4
SCHEMBL50828 0.84 KDM4E (0.32) KDM4ESMN1; SMN2ALDH1A1
SCHEMBL1517521 0.81 ALDH1A1 (0.52) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA
SCHEMBL27813923 0.81 ALDH1A1 (0.50) TRPA1ALDH1A1TP53TSHR
SCHEMBL100085 0.81 ALDH1A1 (0.50) TRPA1ALDH1A1TP53TSHR
SCHEMBL7133107 0.80 KDM4E (0.31) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4
SCHEMBL6436040 0.78 CYP1A2 (0.42) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4
SCHEMBL6434123 0.78 CYP1A2 (0.42) CYP1A2KDM4EHPGDSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10818493-B2 Silicon-based hardmask ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2020-10-27 US disclosed
US-20190115209-A1 SILICON-BASED HARDMASK ROHM & HAAS ELECT MAT (US) 2019-04-18 US disclosed
US-10186424-B2 Silicon-based hardmask ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2019-01-22 US disclosed
US-20180366319-A1 SILICON-BASED HARDMASK ROHM & HAAS ELECT MAT (US) 2018-12-20 US disclosed
US-20100003204-A1 Nanoparticle hybrid sunscreens ENERGY MATERIALS CORPORATION (US) 2010-01-07 US disclosed
EP-1276807-B1 CURABLE SILICONE RESIN COMPOSITION AND REACTIVE SILICON COMPOUNDS DOW CORNING (US) 2005-10-12 EP disclosed
US-6780471-B2 USING CROSSLINKER WITH NONFLEXIBLE LINKAGE INCLUDING AT LEAST ONE P-ARYLENE MOIETY FOR SPATIAL SEPARATION; FLEXURAL STRENGTH, FRACTURE TOUGHNESS, MODULUS AND/OR MECHANICAL DAMPING DOW CORNING CORPORATION 2004-08-24 US disclosed
US-20030130389-A1 Curable silicone resin composition and reactive silicon compounds DOW CORNING LIMITED (GB) 2003-07-10 US disclosed