Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.83 |
| ▸ | RECQL | P46063 | 3/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.83 |
| ▸ | POLB | P06746 | 2/20 | 0.83 |
| ▸ | APEX1 | P27695 | 2/20 | 0.83 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.83 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.83 |
| ▸ | PLG | P00747 | 1/20 | 0.81 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.79 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.78 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.78 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.67 |
| ▸ | TUBB | P07437 | 2/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kumatakenin SCHEMBL29681818 | 1.00 | KDM4E (0.83) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL30131217 | 0.95 | CYP3A4 (0.88) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL4649968 | 0.95 | CYP3A4 (0.88) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL11096763 | 0.91 | ABCG2 (0.77) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL18130384 | 0.91 | ABCB1 (0.83) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| Isokaempferide SCHEMBL29721227 | 0.91 | POLH (1.00) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| Isokaempferide SCHEMBL1628023 | 0.91 | POLH (1.00) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL29825010 | 0.90 | PLG (1.00) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL828941 | 0.90 | PLG (1.00) | KDM4ECYP3A4RECQLCYP2D6POLB | |
| SCHEMBL15635199 | 0.90 | ADORA3 (0.83) | KDM4ECYP3A4RECQLCYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200164047-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | UNIVERSITÀ DEGLI STUDI DI MILANO (IT) | 2020-05-28 | — | — | US | claimed |
| EP-3642337-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2020-04-29 | — | — | EP | claimed |
| WO-2018211137-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | UNIVERSITÀ DEGLI STUDI DI MILANO (IT) | 2018-11-22 | — | — | WO | claimed |
| EP-0290442-A4 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. | CHEMEX PHARMACEUTICALS INC (US) | 1990-07-03 | — | — | EP | claimed |
| EP-0290442-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-11-17 | — | — | EP | claimed |
| US-4774229-A | ANTITUMOR AGENTS, SKIN DISORDERS, CANCER TREATMENT | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-09-27 | — | — | US | claimed |
| WO-1988003805-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-06-02 | — | — | WO | claimed |
| WO-1987006833-A1 | MODIFICATION OF PLANT EXTRACTS FROM ZYGOPHYLLACEAE | CHEMEX PHARMACEUTICALS, INC. (US) | 1987-11-19 | — | — | WO | claimed |
| US-4352792-A | 3-Alkoxyflavone antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | claimed |
| EP-0019081-A1 | Flavone derivatives, their preparation, these novel and known flavones as antiviral agents, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | claimed |
| US-20200164047-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | UNIVERSITÀ DEGLI STUDI DI MILANO (IT) | 2020-05-28 | — | — | US | disclosed |
| EP-3642337-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018211137-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | UNIVERSITÀ DEGLI STUDI DI MILANO (IT) | 2018-11-22 | — | — | WO | disclosed |
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8748177-B2 | Compositions for proliferation of cells and related methods | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-06-10 | — | — | US | disclosed |
| US-4774229-A | ANTITUMOR AGENTS, SKIN DISORDERS, CANCER TREATMENT | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-09-27 | — | — | US | disclosed |
| WO-1987006833-A1 | MODIFICATION OF PLANT EXTRACTS FROM ZYGOPHYLLACEAE | CHEMEX PHARMACEUTICALS, INC. (US) | 1987-11-19 | — | — | WO | disclosed |
| EP-0019081-B1 | FLAVONE DERIVATIVES, THEIR PREPARATION, THESE NOVEL AND KNOWN FLAVONES AS ANTIVIRAL AGENTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-24 | — | — | EP | disclosed |
| US-4352792-A | 3-Alkoxyflavone antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0019081-A1 | Flavone derivatives, their preparation, these novel and known flavones as antiviral agents, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200164047-A1 | THERAPY AND DIAGNOSIS OF DISEASE CHARACTERIZED BY ALTERATIONS IN THE DNA DAMAGE RESPONSE | PPP3CA, PPP5C, PPP3R1 | KDM4E 3052/4885CYP3A4 4698/4885RECQL 139/4885 |
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | KDM4E 674/4885CYP3A4 4005/4885RECQL 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.