Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | DHCR24 | Q15392 | 11/20 | 0.74 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.61 |
| ▸ | RORC | P51449 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847506 | 1.00 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL24300840 | 1.00 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL188329 | 1.00 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL335520 | 1.00 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL30650209 | 0.93 | ALDH1A1 (0.71) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL9155413 | 0.90 | RORC (0.80) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL15123702 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL7624350 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL14911153 | 0.87 | ALDH1A1 (0.80) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL1957035 | 0.85 | USP2 (1.00) | ALDH1A1MEN1KMT2AUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636139-B1 | ISOLATION OF STEROIDS CONTAINING A 5,7-DIENE FUNCTIONALITY FROM A STEROL MIXTURE | STANFORD RES INST INT (US) | 1999-11-17 | — | — | EP | claimed |
| US-12023318-B2 | Therapy for Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) | UCL BUSINESS LTD (GB) | 2024-07-02 | — | — | US | disclosed |
| US-20230047961-A1 | THE CHOLESTEROL-SYNTESIS INTERMEDIATES FOR TREATMENT DEMYELINATING DISORDERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2023-02-16 | — | — | US | disclosed |
| US-20230033795-A1 | NEW THERAPY | UCL BUSINESS LTD (GB) | 2023-02-02 | — | — | US | disclosed |
| US-8097632-B2 | Blocking hedgehog protein transduction signal passageway using alkaloid steroid | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110009615-A1 | METHOD FOR PRODUCING A STEROID COMPOUND | MITSUBISHI CHEMICAL GROUP SCIENCE AND TECHNOLOGY RESEARCH CENTER, INC. (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20100273818-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2010-10-28 | — | — | US | disclosed |
| US-20100063272-A1 | METHOD FOR PRODUCING STEROID COMPOUND | MITSUBISHI CHEMICAL CORPORATION (JP) | 2010-03-11 | — | — | US | disclosed |
| EP-1985621-A1 | PROCESS FOR PRODUCTION OF STEROIDS | Mitsubishi Chemical Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | disclosed |
| US-7291626-B1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2007-11-06 | — | — | US | disclosed |
| US-20060252948-A1 | Production method of steroid compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | disclosed |
| US-20050132430-A1 | Igamete recruitment and developmental competence in mammals by inhibiting the de-nova sterol biosynthesis and/or promoting sterol efflux | RIGSHOSPITALET (DK) | 2005-06-16 | — | — | US | disclosed |
| US-6867216-B1 | Inhibitors of hedgehog signal pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1463804-A1 | IMPROVED GAMETE RECRUITMENT AND DEVELOPMENTAL COMPETENCE IN MAMMALS BY INHIBITING THE DE NOVO STEROL BIOSYNTHESIS AND/OR PROMOTING STEROL EFFLUX | Rigshospitalet (DK) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003055991-A1 | IGAMETE RECRUITMENT AND DEVELOPMENTAL COMPETENCE IN MAMMALS BY INHIBITING THE DE NOVO STEROL BIOSYNTHESIS AND/OR PROMOTING STEROL EFFLUX | RIGSHOSPITALET (DK) | 2003-07-10 | — | — | WO | disclosed |
| US-6225075-B1 | DNA encoding sterol methyltransferase | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. | 2001-05-01 | — | — | US | disclosed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009615-A1 | METHOD FOR PRODUCING A STEROID COMPOUND | CYP46A1, DHCR7, CYP17A1 | ALDH1A1 788/4885MEN1 1713/4885KMT2A 3733/4885 |
| US-20100273818-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | ALDH1A1 3674/4885MEN1 923/4885KMT2A 3380/4885 |
| US-20230033795-A1 | NEW THERAPY | HMGCR, CYP46A1, DHCR7 | ALDH1A1 889/4885MEN1 4657/4885KMT2A 3555/4885 |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | ALDH1A1 3614/4885MEN1 1092/4885KMT2A 3422/4885 |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | ALDH1A1 3674/4885MEN1 923/4885KMT2A 3380/4885 |
| US-20060252948-A1 | Production method of steroid compound | CYP46A1, DHCR7, CYP51A1 | ALDH1A1 811/4885MEN1 1760/4885KMT2A 3953/4885 |
| US-20100063272-A1 | METHOD FOR PRODUCING STEROID COMPOUND | CYP46A1, DHCR7, HSD17B7 | ALDH1A1 879/4885MEN1 1625/4885KMT2A 3863/4885 |
| US-20230047961-A1 | THE CHOLESTEROL-SYNTESIS INTERMEDIATES FOR TREATMENT DEMYELINATING DISORDERS | HMGCR, SGMS1, CETP | ALDH1A1 4421/4885MEN1 607/4885KMT2A 4168/4885 |
| US-12023318-B2 | Therapy for Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) | HMGCR, LDLR, HMGB2 | ALDH1A1 842/4885MEN1 1900/4885KMT2A 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.