Corosolic Acid

Corosolic Acid

SCHEMBL335528

C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 3/20 1.00
POLB P06746 3/20 1.00
PTPN2 P17706 2/20 1.00
PTPN1 P18031 2/20 1.00
PTPN6 P29350 2/20 1.00
GPBAR1 Q8TDU6 2/20 1.00
USP7 Q93009 2/20 1.00
PYGM P11217 1/20 1.00
HTT P42858 1/20 1.00
AKR1B10 O60218 2/20 0.80
AKR1B1 P15121 2/20 0.80
GABRP O00591 1/20 0.80
GABRD O14764 1/20 0.80
GABRA1 P14867 1/20 0.80
GABRB1 P18505 1/20 0.80
GABRG2 P18507 1/20 0.80
GABRB3 P28472 1/20 0.80
GABRA5 P31644 1/20 0.80
GABRA3 P34903 1/20 0.80
GABRA2 P47869 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Corosolic Acid SCHEMBL3290746 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL1280250 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL13735311 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL4456541 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL12181612 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL4962208 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL7921115 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL12740947 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL13629638 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL22027588 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2019 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122005630-A Extraction method of Cordyceps pseudoblack and medicinal application of extract thereof 山西大学 2026-05-12 CN claimed
EP-4734960-A1 STEROL ANALOGS IN LIPID NANOPARTICLE FORMULATIONS Sanofi Pasteur Inc. (US) 2026-05-06 EP claimed
US-12605351-B2 Method for producing a composition comprising a 3-O-p-coumaroyl ester of tormentic acid from a plant cell culture, applications thereof as antiparasitic agent for the treatment of trypanosomiasis LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LU) 2026-04-21 US claimed
US-20260053768-A1 Sustained Nitric Oxide Releasing Drug Delivery Systems HADAYA MAHER (US) 2026-02-26 US claimed
EP-4673117-A1 LOW DOSE THERAPEUTIC SUPPLEMENT TO MODULATE CYTOKINES Virbac Corporation (US) 2026-01-07 EP claimed
EP-4529452-B1 DOSAGE FORMS FOR TOPICAL ADMINISTRATION OF PENTACYCLIC TRITERPENES GIULIANI SPA (IT) 2025-12-24 EP claimed
US-20250367305-A1 ALBUMIN NANOCOMPOSITE COMPRISING PHYTOCHEMICAL AND COMPOSITION FOR IMPROVING MUSCLE DISEASE CONTAINING SAME SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2025-12-04 US claimed
WO-2025235336-A1 SUSTAINED NITRIC OXIDE RELEASING DRUG DELIVERY SYSTEMS HADAYA MAHER (US) 2025-11-13 WO claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
EP-4635507-A1 GLYCAEMIA REGULATING COMPOSITIONS Carbet Medica Srl (IT) 2025-10-22 EP claimed
US-6572897-B1 Alpha Lipoic Acid; Chromium Polynicotinate; Quercetin; Rutin; Lutein; Mormordical Charantia Extract; Corosolic Acid; and Gymnema Sylvestre Extract VITACOST.COM, INC. 2003-06-03 US claimed
US-20030072822-A1 Methods for treating disorders using plant extracts RUTGERS, THE STATE OF UNIVERSITY OF NEW JERSEY 2003-04-17 US claimed
WO-2003020026-A1 METHODS FOR TREATING DISORDERS USING PLANT EXTRACTS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2003-03-13 WO claimed
US-20030008025-A1 Composition for inhibiting increase of blood sugar level or lowering blood sugar level MATSUYAMA FUTOSHI (JP) 2003-01-09 US claimed
US-6485760-B2 CONCENTRATE OF A HOT WATER OR ALCOHOL EXTRACT OF LAGERSTROEMIA SPECIOSA, LINN. OR PERS. (A MEMBER OF LOOSESTRIFE FAMILY) HAVING A SPECIFIED COROSOLIC ACID CONTENT; DOSAGE FORMS MATSUYAMA FUTOSHI (JP) 2002-11-26 US claimed
US-20010006941-A1 COMPOSITION FOR INHIBITING INCREASE OF BLOOD SUGAR LEVEL OR LOWERING BLOOD SUGAR LEVEL MATUYAMA FUTOSHI (JP) 2001-07-05 US claimed
US-20010000474-A1 Comprising a concentrate of a hot water or alcohol extract of leaves of Lagerstroemia Speciosa, Linn. or Pers. and has a specfied corosolic acid content; oral administration to treat diabetes MATSUYAMA FUTOSHI (JP) 2001-04-26 US claimed
CN-1277035-A Volatile liquid composition for inhibiting hyperglycemia, and its volatiling device and its use APPLIC TECHNOLOGY K K (JP) 2000-12-20 CN claimed
EP-1055428-A1 Liquid composition to be vaporized for inhibiting increase in blood sugar level, vaporizer for the same and use of the same USE Techno Corporation (JP) 2000-11-29 EP claimed
EP-1022022-A1 Composition for inhibiting increase of blood sugar level or lowering blood sugar level Matsuyama, Futoshi, c/o Use Techno Corporation (JP) 2000-07-26 EP claimed