SCHEMBL335632

SCHEMBL335632

O=C(O)c1cc2sccc2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 6/20 1.00
HRH4 Q9H3N8 1/20 0.55
TSHR P16473 3/20 0.51
KDM4E B2RXH2 5/20 0.50
HSD17B10 Q99714 5/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
HPGD P15428 3/20 0.48
MAPT P10636 1/20 0.48
SRD5A2 P31213 1/20 0.48
SMAD3 P84022 1/20 0.46
GPR35 Q9HC97 3/20 0.44
ALDH1A1 P00352 3/20 0.44
CYP2C19 P33261 2/20 0.44
NFKB1 P19838 2/20 0.44
LMNA P02545 2/20 0.44
F7 P08709 1/20 0.44
F3 P13726 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3457060 0.82 DAO (0.70) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL2327781 0.82 DAO (0.70) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL3173051 0.82 DAO (0.70) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL6630374 0.78 DAO (0.64) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL30147642 0.78 DAO (0.64) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL24198807 0.78 DAO (0.64) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL1243954 0.78 DAO (0.64) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL4146436 0.76 DAO (0.61) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL14434543 0.75 DAO (0.60) DAOHRH4TSHRKDM4EHSD17B10
SCHEMBL1161150 0.74 DAO (0.58) DAOHRH4TSHRKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108350034-B Antimicrobial polymyxin derived compounds 莫纳什大学 2022-03-11 CN claimed
CN-102614514-B GLP-1 acceptor agonists used for treating pains WANG YONGXIANG 2014-12-10 CN claimed
EP-2069289-B1 ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS SANOFI SA (FR) 2013-10-02 EP claimed
WO-2012100748-A1 GLP-1 RECEPTOR AGONIST FOR TREATING PAIN WANG YONGXIANG (CN) 2012-08-02 WO claimed
US-20090306169-A1 Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors BRANDISH PHILIP E 2009-12-10 US claimed
US-20090233949-A1 ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS SANOFI-AVENTIS (FR) 2009-09-17 US claimed
EP-1088824-B1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PFIZER PROD INC (US) 2004-01-07 EP claimed
US-20030195361-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PFIZER INC. 2003-10-16 US claimed
US-20020183369-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors DU BOIS DAISY JOE (US) 2002-12-05 US claimed
US-6399601-B1 ANTIDIABETIC AGENTS; NERVOUS SYSTEM DISORDERS; ANTICHOLESTEROL AGENTS PFIZER INC. 2002-06-04 US claimed
EP-1088824-A2 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-04-04 EP claimed
EP-4587433-A1 3-(1H-INDOLE-2-CARBONYL)-6,6-DIMETHYL-N-((S)-1-OXO-3-((S)-2-OXOPYRROLIDIN-3-YL)P ROPAN-2-YL)-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE DERIVATIVES AS MPRO INHIBITORS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS Takeda Pharmaceutical Company Limited (JP) 2025-07-23 EP disclosed
EP-4381284-B1 LIGAND-TARGET INTERACTION ANALYSIS BY PHOTOCHEMICALLY INDUCED DYNAMIC NUCLEAR POLARIZATION (PHOTO-CIDNP) ENHANCED NMR SPECTROSCOPY ETH ZUERICH (CH) 2025-07-09 EP disclosed
EP-4577551-A1 HETEROBICYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS Shenzhen Ionova Life Science Co., Ltd. (CN) 2025-07-02 EP disclosed
EP-4573088-A1 HETEROCYCLE RBM39 MODULATORS Recursion Pharmaceuticals, Inc. (US) 2025-06-25 EP disclosed
EP-1157695-A1 Method of treating obesity using a neurotensin receptor ligand Pfizer Products Inc. (US) 2001-11-28 EP disclosed
EP-1136071-A2 Use of glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-09-26 EP disclosed
EP-1127882-A1 Tetrazole compounds as thyroid receptor ligands Pfizer Products Inc. (US) 2001-08-29 EP disclosed
EP-1125580-A2 Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-08-22 EP disclosed
EP-1088824-A2 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306169-A1 Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors DAO, DDO, MAOB DAO 1/4885HRH4 1609/4885TSHR 4179/4885
US-20030195361-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PYGL, GYS1, PYGM DAO 1915/4885HRH4 3088/4885TSHR 3091/4885
US-20090233949-A1 ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS TFPI, F2, F9 DAO 286/4885HRH4 3677/4885TSHR 4084/4885
US-20020183369-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PYGL, PYGM, PYGB DAO 1906/4885HRH4 3448/4885TSHR 3267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.