Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.60 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830625 | 0.89 | TEAD1 (0.73) | TEAD1TEAD3ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12813411 | 0.87 | TP53 (0.51) | KDM4EALDH1A1LMNACHRM4SMN1; SMN2 | |
| SCHEMBL3358504 | 0.86 | YAP1 (0.65) | TEAD1TEAD3KDM4E | |
| SCHEMBL22319836 | 0.85 | TEAD1 (0.46) | TEAD1TEAD3KDM4EALDH1A1LMNA | |
| SCHEMBL22117759 | 0.84 | CHRM4 (0.49) | TEAD1TEAD3ALDH1A1CHRM4SMN1; SMN2 | |
| SCHEMBL5208507 | 0.83 | TEAD1 (0.57) | TEAD1TEAD3KDM4EHTTALDH1A1 | |
| SCHEMBL28064208 | 0.83 | TEAD1 (0.57) | TEAD1TEAD3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27670250 | 0.83 | PARP10 (0.61) | CHRM4NPC1RAB9ALTA4H | |
| SCHEMBL22319868 | 0.82 | KMT2A (0.50) | TEAD1TEAD3KDM4EHTTALDH1A1 | |
| SCHEMBL19610351 | 0.82 | FAAH (0.52) | KDM4EHTTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184313-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-07-18 | — | — | US | disclosed |
| US-8445684-B2 | Nicotinic acetylcholine receptor ligands and the uses thereof | PsycoGenics Inc. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100152450-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | PSYCHOGENICS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152450-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | CHRNG, CHRNA5, CHRNA2 | TEAD1 4723/4885TEAD3 3930/4885KDM4E 2600/4885 |
| US-20130184313-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | CHRNG, CHRNA5, CHRNA2 | TEAD1 4723/4885TEAD3 3930/4885KDM4E 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.