SCHEMBL3357201

SCHEMBL3357201

C=C(Br)C1=C[N]C(=O)NC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14793644 0.80
SCHEMBL3148463 0.67
SCHEMBL14793495 0.63
SCHEMBL3148368 0.63
SCHEMBL143917 0.63
SCHEMBL8552885 0.63
SCHEMBL2042013 0.61
SCHEMBL8884963 0.60
SCHEMBL3357209 0.60
SCHEMBL545786 0.58 HKDC1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3284832-B1 APTAMER WITH IMPROVED RATE OF DISSOCIATION, AND NON-COVALENT APTAMER-TARGET COMPLEX THEREOF SOMALOGIC OPERATING CO INC (US) 2023-06-07 EP claimed
EP-3284832-A2 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES Somalogic, Inc. (US) 2018-02-21 EP claimed
EP-2933340-B1 Aptamers with uridines and/or thymidines substituted at the 5-position with a benzyl group SOMALOGIC INC (US) 2017-09-06 EP claimed
US-20170137819-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2017-05-18 US claimed
EP-2933340-A1 Chemically modified aptamers with improved off-rates Somalogic, Inc. (US) 2015-10-21 EP claimed
US-20150197753-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2015-07-16 US claimed
US-8975388-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2015-03-10 US claimed
US-8404830-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2013-03-26 US claimed
EP-0719273-B1 NUCLEOTIDE ANALOGS GILEAD SCIENCES INC (US) 2010-11-03 EP claimed
US-20040242465-A1 Nucleotide analogs BISCHOFBERGER NORBERT W (US) 2004-12-02 US claimed
US-20040014722-A1 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases BIOCRYST PHARMACEUTICALS, INC. 2004-01-22 US claimed
US-20010041794-A1 Nucleotide analogs GILEAD SCIENCES, INC. 2001-11-15 US claimed
US-6225460-B1 PHOSPHOAMIDATE OR ESTER BOND THAT IS HYDROLYZED IN VIVO TO YIELD A CORRESPONDING PHOSPHONATE NUCLEOTIDE ANALOG. GILEAD SCIENCES, INC. 2001-05-01 US claimed
US-5656745-A AMIDATE LINKAGE; ANTITUMOR, ANTICARCINOGENIC AGENTS GILEAD SCIENCES, INC. (US) 1997-08-12 US claimed
US-8404830-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2013-03-26 US disclosed
EP-0719273-B1 NUCLEOTIDE ANALOGS GILEAD SCIENCES INC (US) 2010-11-03 EP disclosed
WO-2004106350-A1 NUCLEOSIDE ANALOGS AS VIRAL POLYMERASE INHIBITORS BIOCRYST PHARMACEUTICAL, INC. (US) 2004-12-09 WO disclosed
US-20040014722-A1 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases BIOCRYST PHARMACEUTICALS, INC. 2004-01-22 US disclosed