Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515180 | 0.84 | IDO1 (0.53) | — | |
| SCHEMBL21104414 | 0.82 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3HTR2AKCNH2 | |
| SCHEMBL19122696 | 0.81 | L3MBTL1 (0.56) | — | |
| SCHEMBL3083039 | 0.80 | MAPT (0.39) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL14562358 | 0.78 | TNF (0.43) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5413666 | 0.78 | SLC6A3 (0.43) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL23706866 | 0.77 | PTGS2 (0.49) | — | |
| SCHEMBL18735813 | 0.75 | MTNR1A (0.37) | — | |
| SCHEMBL21104321 | 0.75 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR2AKCNH2 | |
| SCHEMBL2209260 | 0.74 | TAAR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611790-A | Preparation method of methylthio methyl phenyl ether | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-01-17 | — | — | CN | claimed |
| CN-115611790-A | Preparation method of methylthio methyl phenyl ether | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-01-17 | — | — | CN | disclosed |
| US-20150258092-A1 | RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS | YALE UNIVERSITY (US) | 2015-09-17 | — | — | US | disclosed |
| US-8912150-B2 | Ribosome structure and protein synthesis inhibitors | MELINTA THERAPEUTICS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20140066623-A1 | Ribosome Structure and Protein Synthesis Inhibitors | MELINTA THERAPEUTICS, LLC | 2014-03-06 | — | — | US | disclosed |
| US-8470990-B2 | Ribosome structure and protein synthesis inhibitors | RIB-X PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100204253-A1 | Ribosome Structure and Protein Synthesis Inhibitors | YALE UNIVERSITY (US) | 2010-08-12 | — | — | US | disclosed |
| US-7666849-B2 | ligands that are designed to specifically kill or inhibit the growth of any target organism | RIB-X PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20050272681-A1 | ligands that are designed to specifically kill or inhibit the growth of any target organism | YALE UNIVERSITY (US) | 2005-12-08 | — | — | US | disclosed |
| US-6947845-B2 | Method of identifying molecules that bind to the large ribosomal subunit | YALE UNIVERSITY (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050036997-A1 | Molecular modeling of the binding sites for anisomycin, azithromycin, erythromycin, linezolid, tylosin, carbomycin A, spiramycin, virginiamycin, sparsomycin and blasticidin using the Haloarcular marismortui large ribosomal subunit; drug design and drug screening | YALE UNIVERSITY (US) | 2005-02-17 | — | — | US | disclosed |
| EP-1308457-A1 | Ribosome structure and protein synthesis inhibitors | YALE UNIVERSITY (US) | 2003-05-07 | — | — | EP | disclosed |