Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795904 | 0.84 | LMNA (0.40) | IKBKBCA12CA1CA2CA9 | |
| SCHEMBL2464885 | 0.71 | — | — | |
| SCHEMBL105146 | 0.68 | IKBKB (0.48) | IKBKBGAAMEN1KMT2AKDR | |
| SCHEMBL3823644 | 0.66 | IKBKB (0.49) | IKBKBGAAMEN1KMT2AKDR | |
| SCHEMBL5981249 | 0.63 | CA1 (0.55) | MAPK1MAP2K4MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL20705487 | 0.63 | CA1 (0.55) | MAPK1MAP2K4MAPKAPK2MAPKAPK3MAPK6 | |
| P-Xylene SCHEMBL28147896 | 0.62 | ALDH1A1 (0.58) | GAAMEN1KMT2AKIF11NPSR1 | |
| SCHEMBL3987365 | 0.62 | MAPT (0.49) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL3310365 | 0.62 | SCN9A (0.51) | IKBKBGAAMEN1KMT2AKDR | |
| SCHEMBL3081965 | 0.62 | MKNK1 (0.40) | IKBKBMEN1KMT2AKDRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9370506-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150182506-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-07-02 | — | — | US | disclosed |
| US-20140343045-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-11-20 | — | — | US | disclosed |
| US-8772295-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-10-10 | — | — | US | disclosed |
| US-8389522-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| WO-2010062308-A1 | MODULATORS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343045-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IKBKB 1378/4885GAA 63/4885MEN1 4664/4885 |
| US-20150182506-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IKBKB 1378/4885GAA 63/4885MEN1 4664/4885 |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IKBKB 1378/4885GAA 63/4885MEN1 4664/4885 |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IKBKB 1378/4885GAA 63/4885MEN1 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.