Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 3/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362938 | 0.83 | ZAP70 (0.38) | CYP3A4FGFR3CYP2C19BPTFKAT2B | |
| SCHEMBL1047789 | 0.78 | ZAP70 (0.49) | CYP3A4FGFR3CYP2C19BPTFKAT2B | |
| SCHEMBL3362901 | 0.77 | MAP4K1 (0.44) | PLK1KDRCSNK2A1WEE1CCNT1 | |
| SCHEMBL12928831 | 0.67 | ZAP70 (0.62) | BPTFKAT2BBRD9KDR | |
| SCHEMBL3359073 | 0.65 | TNIK (0.42) | KDRABL1BCR | |
| SCHEMBL3359667 | 0.65 | IMPDH2 (0.40) | — | |
| SCHEMBL3362622 | 0.64 | SYK (0.37) | CCNT1CDK9 | |
| SCHEMBL3358444 | 0.62 | JAK2 (0.39) | CYP3A4CYP2C19 | |
| SCHEMBL3359217 | 0.62 | ZAP70 (0.49) | FLT3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3359641 | 0.61 | ZAP70 (0.41) | KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |