Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362565 | 0.85 | ZAP70 (0.40) | PDE10AZAP70BTKSOS1 | |
| SCHEMBL3358576 | 0.84 | ZAP70 (0.40) | PDE10AZAP70BTKKDRSYK | |
| SCHEMBL3357832 | 0.84 | ZAP70 (0.42) | ZAP70BTKKDRSYKKCNH2 | |
| SCHEMBL3359512 | 0.83 | ZAP70 (0.51) | ZAP70BTKKDRSYKKCNH2 | |
| SCHEMBL1048619 | 0.80 | ZAP70 (0.55) | PDE10AZAP70KDRSYKKCNH2 | |
| SCHEMBL1158133 | 0.76 | ZAP70 (0.48) | ZAP70SYKSOS1 | |
| SCHEMBL3359721 | 0.76 | SYK (0.43) | ZAP70BTKSYK | |
| SCHEMBL3358792 | 0.76 | ZAP70 (0.42) | ZAP70SYK | |
| SCHEMBL3360946 | 0.76 | ZAP70 (0.51) | ZAP70SYK | |
| SCHEMBL3361613 | 0.76 | ZAP70 (0.43) | ZAP70BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |