Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | CD63 | P08962 | 2/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358415 | 0.83 | SYK (0.41) | SYKCD63ZAP70AURKAAURKC | |
| SCHEMBL3358781 | 0.82 | SYK (0.41) | SYKCD63ZAP70AURKAAURKC | |
| SCHEMBL3358248 | 0.81 | ZAP70 (0.44) | MAPTTSHRNR4A1SYKZAP70 | |
| SCHEMBL3359647 | 0.81 | MAPT (0.43) | MAPTTSHRNR4A1SYKCD63 | |
| SCHEMBL3362709 | 0.81 | SYK (0.45) | MAPTSYKCD63ZAP70AURKA | |
| SCHEMBL3359445 | 0.81 | ZAP70 (0.46) | MAPTSYKZAP70AURKABTK | |
| SCHEMBL27826725 | 0.81 | MAPT (0.48) | MAPTTSHRNR4A1SYKCD63 | |
| SCHEMBL3361347 | 0.80 | ZAP70 (0.42) | MAPTTSHRNR4A1SYKCD63 | |
| SCHEMBL3362714 | 0.80 | ABL1 (0.45) | MAPTTSHRNR4A1SYKCD63 | |
| SCHEMBL3359805 | 0.80 | ZAP70 (0.42) | MAPTTSHRNR4A1SYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |