Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 6/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | CD63 | P08962 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362709 | 0.91 | SYK (0.45) | ZAP70SYKBTKCD63AURKA | |
| SCHEMBL3362714 | 0.86 | ABL1 (0.45) | ZAP70SYKBTKCD63AURKA | |
| SCHEMBL3361347 | 0.86 | ZAP70 (0.42) | ZAP70SYKBTKCD63AURKA | |
| SCHEMBL3358764 | 0.86 | SYK (0.42) | ZAP70SYKBTKCD63AURKA | |
| SCHEMBL3362308 | 0.85 | JAK2 (0.46) | ZAP70SYKBTKCD63AURKA | |
| SCHEMBL3358985 | 0.85 | ZAP70 (0.43) | ZAP70BTKAURKAFGFR1SRC | |
| SCHEMBL3358248 | 0.83 | ZAP70 (0.44) | ZAP70SYKBTKMAPTTSHR | |
| SCHEMBL3358758 | 0.81 | SYK (0.44) | ZAP70SYKCD63AURKAMAPT | |
| SCHEMBL3359647 | 0.81 | MAPT (0.43) | ZAP70SYKCD63AURKAMAPT | |
| SCHEMBL3362540 | 0.80 | SYK (0.44) | ZAP70SYKCD63AURKAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |