Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 6/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25791687 | 0.81 | P2RX7 (0.43) | P2RX7FDPSNPC1MKNK1MKNK2 | |
| SCHEMBL2595451 | 0.78 | TDP1 (0.43) | FDPSPTK2BNPC1POLBALDH1A1 | |
| SCHEMBL156347 | 0.77 | NPC1 (0.40) | FDPSPTK2BNPC1POLBALDH1A1 | |
| Phosphoric Acid SCHEMBL29144200 | 0.77 | FDPS (0.51) | P2RX7FDPSNPC1MKNK1MKNK2 | |
| SCHEMBL24782528 | 0.73 | P2RX7 (0.38) | P2RX7FDPSNPC1MKNK1MKNK2 | |
| SCHEMBL10040004 | 0.71 | KDM4E (0.48) | POLBALDH1A1L3MBTL1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9601743 | 0.71 | KDM4E (0.53) | PTK2BALDH1A1ALPGL3MBTL1KDM4E | |
| Phosphoric Acid SCHEMBL27914386 | 0.70 | FDPS (0.47) | P2RX7FDPSALDH1A1L3MBTL1LMNA | |
| SCHEMBL2173729 | 0.69 | CA2 (0.55) | FDPSPTK2BNPC1POLBALDH1A1 | |
| SCHEMBL29733396 | 0.69 | CA2 (0.55) | FDPSPTK2BNPC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709465-B2 | Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-05-04 | — | — | US | disclosed |
| CN-101489380-A | Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers | UNIV ILLINOIS (US) | 2009-07-22 | — | — | CN | disclosed |
| EP-2034828-A2 | PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20090004293-A1 | Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-01 | — | — | US | disclosed |
| WO-2007137200-A2 | PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004293-A1 | Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers | PHOSPHO1, MCL1, MTMR1 | P2RX7 1907/4885FDPS 1636/4885PTK2B 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.