Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359445 | 0.91 | ZAP70 (0.46) | ZAP70JAK2JAK3JAK1TYK2 | |
| SCHEMBL3358764 | 0.89 | SYK (0.42) | ZAP70JAK2BTKMAPTTSHR | |
| SCHEMBL3359805 | 0.83 | ZAP70 (0.42) | ZAP70JAK2BTKMAPTTSHR | |
| SCHEMBL3362709 | 0.82 | SYK (0.45) | ZAP70BTKMAPTSYKBRD4 | |
| SCHEMBL3362620 | 0.82 | ZAP70 (0.42) | ZAP70JAK2JAK3MAPTSYK | |
| SCHEMBL3362308 | 0.82 | JAK2 (0.46) | ZAP70JAK2BTKMAPTTSHR | |
| SCHEMBL3359180 | 0.81 | MAPT (0.50) | ZAP70BTKMAPTTSHRNR4A1 | |
| SCHEMBL3362714 | 0.81 | ABL1 (0.45) | ZAP70JAK2JAK3BTKMAPT | |
| SCHEMBL3361347 | 0.81 | ZAP70 (0.42) | ZAP70BTKMAPTTSHRNR4A1 | |
| SCHEMBL3361081 | 0.81 | SYK (0.48) | ZAP70JAK2JAK3BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |