Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | CD63 | P08962 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359805 | 0.85 | ZAP70 (0.42) | JAK2ZAP70SYKBTKAURKA | |
| SCHEMBL3362709 | 0.85 | SYK (0.45) | ZAP70SYKBTKAURKATNK2 | |
| SCHEMBL3358764 | 0.85 | SYK (0.42) | JAK2ZAP70SYKBTKAURKA | |
| SCHEMBL3362714 | 0.84 | ABL1 (0.45) | JAK2ZAP70SYKBTKPI4KB | |
| SCHEMBL3361347 | 0.84 | ZAP70 (0.42) | ZAP70SYKBTKAURKACD63 | |
| SCHEMBL3358248 | 0.82 | ZAP70 (0.44) | JAK2ZAP70SYKBTKMAPT | |
| SCHEMBL3360211 | 0.80 | JAK2 (0.41) | JAK2SYK | |
| SCHEMBL3359180 | 0.79 | MAPT (0.50) | ZAP70SYKBTKAURKACD63 | |
| SCHEMBL3358758 | 0.79 | SYK (0.44) | JAK2ZAP70SYKAURKACD63 | |
| SCHEMBL3359445 | 0.78 | ZAP70 (0.46) | JAK2ZAP70SYKBTKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |