Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5483468 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL23928058 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL8851046 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL8851421 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL1318750 | 0.93 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL22497667 | 0.93 | — | — | |
| Propylene Glycol SCHEMBL8327833 | 0.93 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL2590009 | 0.93 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL83155 | 0.93 | — | — | |
| Propylene Glycol SCHEMBL3068491 | 0.93 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056982-A1 | Photodynamic therapy for the treatment of acne | QLT INC. (CA) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056982-A1 | Photodynamic therapy for the treatment of acne | PPOX, PPARG, PORCN | TDP1 3515/4885TSHR 2717/4885ALDH1A1 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.